International Conference on Systems Biology in 2018 was held between October 27 and November 1 in Lyon, France. The conference venue was located a couple of hundred meters from the International Criminal Police Organization (INTERPOL) headquarters. Therefore, we all could feel safe. The conference was announced already at ICSB 2017 in Virginia and we could truly enjoy the well-organised event. The institute was represented by Agris Pentjuss and Egils Stalidzans who participated in a number of tutorials (including COPASI) and sessions.