Establishment of Latvian interdisciplinary interuniversity scientific group of systems biology (2009 - 2012)
Project No. 2009/0207/1DP/126.96.36.199.0/09/APIA/VIAA/128
Source of funding: European Structural Fund
Project period: 01.12.2009. – 30.11.2012.
Project budget: 1 900 000 EUR
Project coordinator: Professor Egils Stalidzans (Latvia University of Life Sciences and Technologies, Jelgava, Latvia)
The aim of the project is to attract human resources to science by forming an interdisciplinary group in systems biology, in which computer modelers and experimenters will cooperate.
Research direction: development, optimization and application of dynamic, quantitative computer models in yeast and bacterial metabolic engineering, design of biotechnological processes and development of their control. The experiments will not be based on descriptive notions of the metabolism of microorganisms, but on detailed computer models of metabolism.
Institute of Microbiology and Biotechnology, University of Latvia (Uldis Kalnenieks)
Faculty of Information and Communication Technologies, Latvia University of Life Sciences and Technologies, Jelgava, Latvia (Egils Stalidzans)
Faculty of Material Science and Applied Chemistry, Riga Technical University, Riga, Latvia (Juris Vanags)
Mathematical modeling along with experiments with Zymomonas mobilis and Saccharomyces cerevisae metabolism have led to improved undesrtanding of botechnological potential of both organisms. Mathematical model of Zymomonas mobilis central metabolism has been developed and used to explore the biotechnological potential of the organism and its engineering for different substrate/product combinations.
Total optimisation potential (TOP) approach of kinetic model optimisation has been developed.