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August 14, 2020
Kinetic modeling of pharmacokinetics/ pharmacodynamics (PK/PD)
Pharmacokinetic modeling is used to assess the drug concentration in body fluids and tissues over time resulting from administration of a certain drug dose. Modeling enables to estimate concentration time courses in different tissues even having limited amount of experimental data. The dose can be optimized depending on the means of administration and other parameters.
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Signaling and protein-protein interaction (PPI) networks differ from metabolic processes in many aspects. One can not relay there on mass conservation constraint. At the same time Boolean type of modeling gives effective modeling tool limiting the states just by active (=1) or inactive (=0) states.
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Boolean modeling of signaling and protein-protein interaction networks
August 14, 2020
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August 14, 2020
Kinetic modeling of pharmacokinetics/ pharmacodynamics (PK/PD)
Pharmacokinetic modeling is used to assess the drug concentration in body fluids and tissues over time resulting from administration of a certain drug dose. Modeling enables to estimate concentration time courses in different tissues even having limited amount of experimental data. The dose can be optimized depending on the means of administration and other parameters.
read more
Kinetic modeling of pharmacokinetics/ pharmacodynamics (PK/PD)
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