August 14, 2020

Kinetic modeling of pharmacokinetics/ pharmacodynamics (PK/PD)

Pharmacokinetic modeling is used to assess the drug concentration in body fluids and tissues over time resulting from administration of a certain drug dose. Modeling enables to estimate concentration time courses in different tissues even having limited amount of experimental data. The dose can be optimized depending on the means of administration and other parameters.

Signaling and protein-protein interaction (PPI) networks differ from metabolic processes in many aspects. One can not relay there on mass conservation constraint. At the same time Boolean type of modeling gives effective modeling tool limiting the states just by active (=1) or inactive (=0) states. 

Boolean modeling of signaling and protein-protein interaction networks

August 14, 2020

August 14, 2020

Kinetic modeling of pharmacokinetics/ pharmacodynamics (PK/PD)

Pharmacokinetic modeling is used to assess the drug concentration in body fluids and tissues over time resulting from administration of a certain drug dose. Modeling enables to estimate concentration time courses in different tissues even having limited amount of experimental data. The dose can be optimized depending on the means of administration and other parameters.

Kinetic modeling of pharmacokinetics/ pharmacodynamics (PK/PD)

co-authored COBRA 3.0 paper

VERSIJA 2 / AUTOMĀTISKI PIEVIENOJAS

Institute of Microbiology and Biotechnology, University of Latvia Jelgavas iela 1, Riga
LV-1004, Latvia

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