Pharmacokinetic modeling is used to assess the drug concentration in body fluids and tissues over time resulting from administration of a certain drug dose. Modeling enables to estimate concentration time courses in different tissues even having limited amount of experimental data. The dose can be optimized depending on the means of administration and other parameters.
Knowing the concentration time courses the drug effect (pharmacodynamics) can be assessed establishing the effect time courses resulting from a drug dose.
We have experience in pharmacokinetic modeling of rat and human and plan to extend the research towards pharmacodynamics studies.
Our main modeling tool is the software COPASI. We have used COPASI alone and in combination with COPASI wrapper SpaceScanner to manage parallel optimisation runs of global stochastic optimisation methods.